In late 1955 at the Frankfurt International Motor Show Mercedes revealed the L 319 panel van, the first van since the war and what was effectively the grandfather of the modern-day Sprinter series. It was the next year however when production began, with panel van, flatbed pickup, low-loader, mobile shop, and O 319 minibus versions available. The vehicle's maximum gross weight was 3.6 tonnes, with two available payloads of 1.6 and 1.8 tonnes. 

It featured a rather peculiar design, which was reminiscent of the LP 315 forward control model of the previous year. The front axle was set extremely far forward to allow easier access to the cabin with the doors behind the wheels, giving the vehicle a unique look. At the launch, only one engine was available; the 1.8 litre OM 636 4-cylinder diesel from the 180 D passenger car which produced 43 hp. A year after launch the 190 passenger car's 65hp M 121 1.9 litre 4-cylinder petrol engine became available alongside the diesel. These engines were connected to the rear axle by a 4-speed manual gearbox. Diesel variants were named L 319 D.

Inside, the instrument cluster was very basic - not even a fuel gage was included. At the back however, the L 319 offered a large load area volume of 8.6 cubic metres, due to the set forward position of the driver's cabin.

Until 1962 the van was built in Mercedes' Sindelfingen factory, but during the aforementioned year production was relocated to the then recently acquired Dusseldorf plant, which also supplied parts in the form of unassembled kits to the Vitoria factory in Spain. Panel van based minibuses were constructed in Manheim.

In 1963 the entire truck range's nomenclature was changed after nine years of the previous system. The L 319 became the L 405 and L 407 depending on the horsepower. On the topic of horsepower, 55 hp diesel and 80 hp petrol engines were later added to the range, which made the L 406 and L 408.

Over the twelve year production period the L 319 / L 406 series achieved great popularity, and 140,000 examples of vans, pickups and buses were manufactured.

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